Bioterrorism

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	Bioterrorism Bioterrorism is terrorism using germ warfare, an intentional human release of a naturally-occurring or human-modified toxin or biological agent[?]. The term is difficult to objectively define since there are varying definitions of biowar, biodefense, biosecurity, and also varying definitions of terrorism itself. For instance, the distribution of cholera and smallpox infected blankets to U.S. aboriginals during the 19th century could be considered to be such a deliberate attack. Accordingly, it is perhaps better to refer to 'incidents' rather than 'attacks' and to restrict the term to current rather than any historical event. Biological agents are usually dispersed by an aerosol spray (inhaled or ingested). The main difficulty in mounting an attack is to disperse the agent in a manner that would infect large numbers of people. For example, in dispersing an aerosol, one would have to ensure that the particles would be of exactly the right size, otherwise the particles would quickly leave the atmosphere before moving far from the source or remain in the atmosphere and be diluted before having a chance to infect people. Furthermore, an aerosol that is too large or small would be filtered by the respiratory system either before it reached the lungs or exhaled if it did. They usually have an incubation[?] period of several days before any symptoms appear.

Types of biological agents :

Anthrax : Anthrax is a bacteria with a highly resistant spore form. It is highly infectious and lethal when inhaled. It is a one-time agent that doesn't spread from one person to another. An anthrax vaccine does exist but requires many injections and has enough side-effects that it is considered unsuitable for general use.

Smallpox : Smallpox is a highly contagious virus. It transmits easily through the atmosphere and has a high mortality rate. Smallpox was eliminated in the world in the 1970s thanks to a worldwide vaccination program. However, some virus are still available in russian and american laboratories. It is also believed it could be available in other labs.

Botulism: Botulism is one the deadliest toxins caused by a bacteria. Botulism causes respiratory failure and paralysis.

Ebola: Ebola is a viral hemorrhagic fever. It is extremely lethal, with no cure. The symptoms are profuse bleeding from the orifices.

Plague: Plague is a highly contagious bacteria. It causes a type of pneumonia and may be fatal.

Marburg: Marburg is a viral hemorrhagic disease. It is extremely lethal, with no cure.

Tularemia[?]: Tularemia is a bacteria, responsable for non-lethal but extremely incapacitating diseases (weight loss, fever, headaches, and often pneumonia).

Biological warfare programs and convention on biological weapons

The United States' biological warfare programme began during WWII. But, it came to a halt in 1969, when President Nixon reviewed the program, decided it was wrong, and ordered the destruction of all weapons. Part of the decision was due to the availability in nuclear defense, which, it was thought, made it unnecessary to develop biological weapons since it would make it possible for other countries to develop them as well.

Today, several countries have or are developing biological warfare programmes. According to the U.S. Department of Defense, more than ten countries have, or are developing biological warfare programs, among which, The United States of America, Russia, Israel, Egypt, China, Iran, Iraq, Libya, Syria and North Korea.

Offensive biological weapons were banned by the 1972 multi-lateral treaty. The goal of the treaty was to eliminated biological weapon systems. In 1996, 137 countries had signed the treaty.

modern Bioterrorist incidents

2001 anthrax attack

Planning and reacting to a bioterrorist attack

Planning may involve the development of biological identification systems.

Until recently in the United States of America, most biological defense strategies have been geared to protecting soldiers on the battlefield rather than ordinary people in cities. Financial cutbacks have limited the tracking of disease outbreaks. Some like food poisoning due to E. Coli or Salmonella could be natural or deliberate.

In Europe, disease surveillance is beginning to be organised on the continent-wide scale needed to track a biological emergency. In addition of monitoring sick people, it is thought interesting to track whether a disease is due to natural outbreaks or deliberate attack. For example, a natural variety of anthrax occur in South Africa.

Researchers are experimenting with devices to detect the existence of a threat

tiny electronic chips that would contain living nerve cells to warn of the presence of bacterial toxins (identification of broad range toxins)
fibre-optic tube lined with antibodies coupled to light-emitting molecules (identification of specific pathogens, such as anthrax, botulin, ricin)

Plants as sensors

Very recently, public research has been approved to set up some genetically modified plants that could, in an immediate future, being made profitable to alert the population and the authorities in the event of chemical or biological attack. These new plants specifically modified would change color in contact with certain chemical elements, or biological agents, likely to be used at the time of possible terrorist attacks. The plants - opportunely placed in public places - would lose their green color quickly, thus setting off the alarm.

Arguments given to justify this option is that people are used to plants much more than to chemical sensors and the use in public places would not worry the population. Another argument is that these gmos[?] sentinels could be deployed on vast geographical areas and their system of detection could be introduced into the evergreen trees and the algae of the watery zones, making it possible the satellites to supervise and perceive any change of color due to an hostile agent.

Reaction involves

setting up local emergency rooms and offices to immediately deal with the outcome in case of an attack
instruction and training for local communities
protective clothing for military personnel
tracking down of people buying materials involved in biological warfare

Once the biological agent has been identified, it can be fought through vaccination of people before they are exposed. However, vaccines are not considered to be a perfect solution. A bioterrorist could develop novel, possibly artificial, pathogens against which conventional vaccines would be useless.

Consequently, some suggest that it would be interesting to look for ways of developing vaccines quickly enough for them to be created, mass-produced and distributed after an attack. This could involve progress in DNA sequencing so that an unknown pathogen's genes could be known very quickly. The resulting sequences could help in the development of an instant DNA vaccine.

Another major issue with vaccines is that they often have side-effects which are sometimes lethal, and hence a massive innoculation program may result in deaths and illness which would be unnecessary if no biowarfare attack occurs. This issue has a particular with the smallpox and anthrax vaccines.

Making the vaccine isn't the totality of the solution. It is rather easy to order soldiers to take the vaccine, but immunizing the population isn't, in particular with a vaccine making people sick, with all the controversies already going around vaccination.

For these reasons, some feel that researchers should concentrate on ways to treat victims of biological weapons. For example, Ebola kills people by inducing a widespread inflammatory reaction (similar to toxic shock syndrome). This could be fought by a new and very powerful anti-inflammatory drug.